Lycorine HCl
Protein synthesis inhibitor/SCAP degrader / Arrests cell cycle at G2/M phase and induces apoptosis in tumor cells.1 Inhibits human enterovirus 71 replication by blocking elongation of the viral polyprotein during translation and reduces viral cytopathic effects in mice.2 Dose-dependently extends the circadian period length in mammalian cells by enhancing Bmal1 transcription.3 Selectively inhibits human ovarian cancer cell proliferation and neovascularization (IC50=1.2 µM4. A potent SREBF chaperone (SCAP) degrader (Kd=15.24 nM) which acts via an autophagy-independent lysosomal pathway.5
Biochemicals & reagents
2188-68-3
Galanthidine; Amarylline; Narcissine
1) Miliauskas et al. (2005), Identification of radical scavenging compounds in Rhaponticum carthamoides by means of LC-DAD-SPE-NMR; J. Nat. Prod., 68 168 2) Liu et al. (2011), Lycorine reduces mortality of human enterovirus 71-infected mice by inhibiting virus replication; Virol. J., 8 483 3) Onishi et al. (2012), Lycorine, a candidate for the control of period length in mammalian cells; Cell Physiol. Biochem., 29 407 4) Cao et al. (2013), Lycorine hydrochloride selectively inhibits human ovarian cancer cell proliferation and tumor neovascularization with very low toxicity; Toxicol. Lett., 218 174 5) Zheng et al. (2020), Thw Paf1 complex transcriptionally regulates the mitochondrial anchored protein Atg32 leading to activation of mitophagy; Autophagy, 20 1
RT
TARGET: Ribosome; Lysosome; Antioxidant -- PATHWAY: Cell cycle; Proliferation; Apoptosis inducer; Protein synthesis -- RESEARCH AREA: Cell death; Angiogenesis; Circadian clock; Neuroscience -- DISEASE AREA: Cancer; Infectious diseaseDiabetes; Neurodegeneration