Hinokitiol
Iron Chelator antioxidant / Hinokitiol is a potent metal chelator that induces differentiation and apoptosis in teratocarcinoma F9 cells.1 It acts as a reversible inhibitor of platelet-type 12-lipoxygenase (IC50 = 100 nM).2 Reported to have strong antibacterial activity3, suppress cell growth and disrupt androgen receptor signaling4 and activate hypoxia-inducible factor5.
Biochemicals & reagents
499-44-5
1) Ido et al (1999) Induction of apoptosis by hinokitiol, a potent iron chelator, in teratocarcinoma F9 cells is mediated through the activation of caspase-3, Cell Prolif. 32 63 / 2) Suzuki et al. (2000) Hinokitiol, a selective inhibitor of the platelet-type isozyme of arachidonate 12-lipoxygenase, Biochem.Biophys.Res.Commun. 275 885 / 3) Morita et al. (2007) The mechanism of the bactericidal activity of hinokitiol, Biocontrol Sci. 12 101. / 4) Liu and Yamauchi (2006) Hinokitiol, a metal chelator derived from natural plants, suppresses cell growth and disrupts androgen receptor signaling in prostate carcinoma cell lines, Biochem.Biophys.Res.Commun. 351 26 / 5) Lee et al. (2010) Hinokitiol activates the hypoxia-inducible factor (HIF) pathway through inhibition of HIF hydroxylases, Biochem.Biophys.Res.Commun. 396 370
RT
TARGET: Chelator; LOX (Lipoxygenase); Antioxidant -- PATHWAY: Apoptosis inducer; Redox; EGF -- RESEARCH AREA: Oxidative stress; Cell death; Neuroscience -- DISEASE AREA: Infectious disease; CancerNeurodegeneration