Ivermectin
Nuclear transport inhibitor / A specific inhibitor of importin α/-mediated nuclear import with no effect on a range of other nuclear import pathways.1. Displays potent antiviral activity against HIV-1, dengue1, corona2 and other viruses. Clinically useful broad-spectrum antiparasitic agent.3
Biochemicals & reagents
70288-86-7
22,23-Dihydro C076B1; MK-933
1) Wagstaff et al. (2012), Ivermectin is a specific inhibitor of importin ?/ß-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus; Biochem. J., 443 851 2) Caly et al. (2020), The FDA-approved drug ivermectininhibits the replication of SARS-CoV-2 in vitro; Antiviral Res., 178 104787 3) Ottesen and Campbell (1994), Ivermectin in human medicine; J. Antimicrob. Chemother., 34 195
-20°C
PATHWAY: Nuclear transport -- DISEASE AREA: Infectious disease; Parasites