Cepharanthine
Autophagy inhibitor with antiviral activity / A naturally occurring alkaloid from Stephania cepharantha Hayata which possesses a number of pharmacological activities.1 Attenuates LPS-induced expression of TNF-α, IL-6 and IL-1 in macrophages and inhibits NF-B activation.2 Induces mitophagy possibly by acting at GPR30 in hepatocellular carcinoma.3 Inhibits autophagosome-lysosome fusion and autophagy by downregulation of MYO1C an actin-based motor protein.4 Potently inhibits replication of SARS CoV-2 and homologous viruses.5
Biochemicals & reagents
481-49-2
O-Methylcepharanoline; NSC 623442
1) Rogosnitzky and Dank (2011), Therapeutic potential of the biscoclaurine alkaloid, cepharanthine, for a range of clinical conditions; Pharmacol. Rep., 63 337 2) Huang et al. (2014), Cepharanthine, an alkaloid from Stephania cepharantha Hayata inhibits the inflammatory response in the RAW264.7 cell and mouse models; Inflammation, 37 235 3) Wang et al. (2020), Cepharanthine hydrochloride induces mitophagy targeting GPR30 in hepatocellular carcinoma (HCC); Expert Opin. Ther. Targets, 24 389 4) Zhang et al. (2019), Downregulation of MYO1C mediated by cepharanthine inhibits autophagosome-lysosome fusion through blockade of the F-actin network; J. Exp. Clin. Cancer Res. 38 457 5) Rosognitzky et al. (2020), Cepharanthine: a review of the antiviral potential of a Japanese-approved alopecia drug in COVID-19; Pharmacol. Rep., July 22:1 Online Ahead of Print
-20°C
TARGET: Cytochrome/MDR; Lysosome; HSP (Heat shock protein) -- PATHWAY: Mitophagy; Apoptosis inducer; NFkappaB; AMPK pathway; Proliferation; Autophagy -- RESEARCH AREA: Cell death; Immunology; Oxidative stress -- DISEASE AREA: Inflammation; CancerInfectious disease; Parasites; Hypertension