Importazole
Blocks importin-b-mediated nuclear import / Specifically inhibits importin-β-mediated nuclear import without disrupting transportin-mediated nuclear import or CRM1-mediated nuclear export1. When added to cells during mitosis it impairs the release of an importin- cargo probe and causes defects in spindle assembly. Inhibition of importin-β function is most likely mediated by blocking its interaction with RanGTP. It is an important new tool to probe the function of the importin-/RanGTP pathway2-4. Cell permeable
Biochemicals & reagents
662163-81-7
IPZ
1) Soderholm et al. (2011), Importazole, a small molecule inhibitor of the transport receptor importin-β; ACS Chem. Biol., 6 700 2) Bird et al. (2013), RanGTP and CLASP1 cooperate to position the mitotic spindle; Mol. Biol. Cell, 24 2506 3) Bai et al. (2014), Importin β-dependent nuclear import of TopBP1 in ATR-Chk1 checkpoint in Xenopus egg extracts; Cell Signal., 26 857 4) Yan et al. (2015), Importin β1 mediates nuclear factor-kB signal transduction into the nuclei of myeloma cells and affects their proliferation and apoptosis; Cell Signal., 27 851
RT
PATHWAY: Nuclear transport; Cytoskeleton