Hedgehog pathway inhibitor / HPI-1 is a Hedgehog pathway inhibitor acting downstream of Smo and independently of PKA, PI3K and MAPK. It can suppress Hh pathway activation induced by loss of Su(fu) or Gli overexpression. Inhibits both endogenous and exogenous Gli1/Gli2 activity. IC50’s range from 0.2 to 6 µM for various cell-based assays.
Product Type:
Biochemicals & reagents
CAS Number:
599150-20-6
Reference:
1) Hyman et al. (2009) Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade. Proc.Natl.Acad.Sci.USA 106 14132
Storage Temperature:
-20°C
Additional Information:
PATHWAY: Hedgehog; Posttranslational modification