Inducer of definitive endoderm / IDE2 induces robust differentiation of embryonic stem cells into endoderm (EC50 = 223 nM) in both mouse and human cells via activation of the TGFß signaling pathway.1 It was able to induce definitive endoderm in mouse embryonic stem cells in a protocol to create lung alveolar epithelial cells.2
Biochemicals & reagents
1136466-93-7
6-(N’-Cyclopenylidenehydrazinecarbonyl)hexanoic acid
1) Borowiak et al. (2009) Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells; Cell Stem Cell, 4 348 2) Dezfouli et al. (2019) Hydrocortisone Promotes Differentiation of Mouse Embryonic Stem Cell-Derived Definitive Endoderm toward Lung Alveolar Epithelial Cells; Cell J. 20 469
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PATHWAY: TGF-beta -- RESEARCH AREA: Stem cells