L-Cycloserine
Sphingolipid biosynthesis inhibitor / L-Cycloserine down-regulates sphingolipid biosynthesis via inhibition of serine palmitoyltransferase (3-ketodihydrosphingosine synthetase).1 The L isomer was shown to be 100-fold more potent than the D isomer at inhibition of the brain microsomal enzyme.1 It is a useful pharmacological agent for lowering sphingolipid levels in cells2 as well as in animal models3. Inhibition of de novo ceramide biosynthesis with L-cycloserine positively affected the senescent phenotype, restoring neuronal signaling and reducing mitochondrial dysfunction in a cortical neuronal model of senescence.4
Biochemicals & reagents
339-72-0
L-(-)-Cycloserine; S-Cycloserine
1 Sundaram et al. (1984), Inhibition of sphingolipid synthesis by cycloserine in vitro and in vivo; J. Neurochem. 42 577 2 Ribbens et al. (2014), Characterization and application of a disease-cell model for a neurodegenerative lysosomal disease; Mol. Genet. Metab., 111 172 3 Lewandowski et al. (2022), Inhibition of ceramide accumulation in AdipoR-/- mice increases photoreceptor survival and improves vision; JCI Insight 7 e156301 4 Granzotto et al. (2019), Inhibition of de novo ceramide biosynthesis affects aging phenotype in an in vitro model of neuronal senescence; Aging (Albany NY) 11 6336
-20°C
PATHWAY: Sphingolipid metabolism; Senescence; Mitochondrial function; Fatty acid metabolism -- RESEARCH AREA: Neuroscience