Tiagabine hydrochloiride
GABA transporter 1 (GAT1) inhibitor / Tiagabine is a clinically useful anticonvulsant.1 It is also used to treat anxiety/panic disorder2 and neuropathic pain3. Tiagabine inhibits GABA-reuptake (IC50 [3H]GABA uptake = 67 nM) via inhibiting GABA transporter 1(GAT1) blocking both neuronal and glial GABA re-uptake.4,5
Biochemicals & reagents
145821-59-6
NO-325
1) Schacter (1999) A Review of the Antiepileptic Drug Tiagabine, Clin. Neuropharmacol. 22 312 2) Schwartz and Nihalani (2006) Tiagabine in anxiety disorders, Expert Opin. Pharmacother. 7 1977 3) Novak et al. (2001) Treatment of Painful Sensory Neuropathy With Tiagabine: A Pilot Study, Clin. Auton. Res. 11 357 4) Braestrup et al. (1990) (R)-N-[4,4-bis(3-methyl-2-thienyl)but-3-en-1-yl)nipecotic Acid Binds With High Affinity to the Brain Gamma-Aminobutyric Acid Uptake Carrier, J.Neurochem. 54 639 5) Nielsen et al. (1991) Characterization of Tiagabine (NO-328), a New Potent and Selective GABA Uptake Inhibitor, Eur. J. Pharmacol. 196 257
-20°C
RESEARCH AREA: Neuroscience -- DISEASE AREA: Pain; Mood disorders