Cardamonin
NFκB inhibitor / Inhibits NF-κB activation via inhibition of IκBα degradation and phosphorylation, IκB kinase activation and NF-κB nuclear translocation1,2. Displays anti-inflammatory activity in various models3. Cell permeable.
Biochemicals & reagents
19309-14-9
1) Lee et al. (2006), Blockade of nuclear factor-kappaB signaling pathway and anti-inflammatory activity of cardamomin, a chalcone analog from Alpinia conchigera; J. Pharmacol. Exp. Ther., 316 271 2) Israf et al. (2007), Cardamonin inhibits COX and iNOS expression via inhibition of p65NF-kappaB nuclear translocation and Ikappa-B phosphorylation in RAW 264.7 macrophage cells; Mol. Immunol., 44 673 3) Ahmad et al. (2006), Cardamonin, inhibits pro-inflammatory mediators in activated RAW 264.7 cells and whole blood; Eur. Phamracol. Exp. Ther., 538 188
-20°C
PATHWAY: NFkappaB; Redox; Cytokine -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Pain; AddictionInflammation; Diabetes; Cancer