Selective circadian clock protein CRY1 stabilizer / KL101 is an isoform-selective stabilizer of the circadian clock protein CRY1. It dose-dependently lengthened the circadian period in Bmal1-dLuc and Per2-dLuc reporter cells. KL101 strongly enhanced rosiglitazone-dependent brown adipocyte differentiation revealing the importance of CRY-dependent regulation of energy metabolism and a possible new lead for anti-obesity therapeutics.
Product Type:
Biochemicals & reagents
CAS Number:
396721-89-4
Reference:
1) Miller et al. (2020), Isoform-selective regulation of mammalian cryptochromes; Nat. Chem. Biol. 16 676
Storage Temperature:
-20°C
Additional Information:
RESEARCH AREA: Circadian clock -- DISEASE AREA: Obesity; Diabetes