N-Myristoylglycine
Endogenous brown fat-inducing lipid / An endogenous lipid which was found to differentiate adipocyte precursors and white-biased adipocytes into functional brown adipocytes.1 Blood plasma and urine biomarker of primary dysmenorrhea.2 A standard for analysis of N-terminal myristoylated peptides and proteins.3,4 Enzymatically produced in mammals from myristoyl-coenzyme A and glycine by acyl-CoA:glycine N-acyltransferase.5
Biochemicals & reagents
14246-55-0
Myristoyl glycine; NSC622050; Myr-Gly
1 Guijas et al. (2022), Drug-Initiated Activity Metabolomics Identifies Myristoylglycine as a Potent Endogenous Metabolite for Human Brown Fat Differentiation; Metabolites, 12 749 2 Liu et al. (2013), Biomarkers of primary dysmenorrhea and herbal formula intervention: an exploratory metabonomics study of blood plasma and urine; Mol. Biosyst., 9 77 3 Okimura et al. (2003), HPLC analysis of fatty acyl-glycine in the aqueous methanesulfonic acid hydrolysates of N-terminally fatty acylated peptides; Biol. Pharm. Bull., 26 1166 4 Resh et al. (2016), Fatty acylation of proteins: The long and the short of it; Prog. Lipid Res., 63 120 5 Merkler et al. (1996), Fatty acid amide biosynthesis: a possible new role for peptidylglycine alpha-amidating enzyme and acyl-coenzyme A: glycine N-acyltransferase; Arch. Biochem. Biophys., 330 430
-20°C
PATHWAY: Fatty acid metabolism; Posttranslational modification; Amino acid metabolism -- RESEARCH AREA: Immunology -- DISEASE AREA: Obesity