Soluble epoxide hydrolase inhibitor / TPPU is a potent and selective inhibitor of both murine and human soluble epoxide hydrolase, IC50=2.8 and 3.7 nM respectively.1 It alleviated blood brain barrier damage and attenuated neuronal injury in a mouse intracerebral hemorrhage model2 and displays neuroprotective effects in ischemic injury3. It reduces neuroinflammation in a mouse model of Alzheimer’s disease.4 It improves insulin resistance and reduced hypertension in mouse models.5 Cell permeable and active in vivo.
Biochemicals & reagents
1222780-33-7
1 Rose et al. (2010), 1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain; J. Med. Chem. 53 7067 2 Tian et al. (2021), Soluble epoxide hydrolase inhibitor attenuates BBB disruption and neuroinflammation after intracerebral hemorrhage in mice; Neurochem. Int. 150 105197 3 Yi et al. (2021), 1-Trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) Urea Exerts Neuro-Protective Effects Against Ischemic Injury via Suppressing JNK/p38 MAPK-Mediated Mitochondrial Apoptosis Pathway; J. Stroke Cerebrovasc. Dis. 30 105957 4 Ghosh et al. (2020), An epoxide hydrolase inhibitor reduces neuroinflammation in a mouse model of Alzheimer’s disease; Sci. Transl. Med. 12 eabb1206 5 Luo et al. (2021), Inhibition of soluble epoxide hydrolase alleviates insulin resistance and hypertension via downregulation of SGLT2 in the mouse kidney; J. Biol. Chem. 296 100667
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PATHWAY: PI3K -- RESEARCH AREA: Neuroscience; Oxidative stress -- DISEASE AREA: Neurodegeneration; PainInflammation; Diabetes; Ischemia