Carboxy-PTIO potassium salt
Nitric oxide scavenger / A nitric oxide (NO) scavenger. Carboxy-PTIO (148819-94-7) reacts with NO with 1:1 stoichiometry1 producing NO2–/NO3–. In LPS-induced endotoxin shock, carboxy-PTIO reversed hypotension and renal dysfunction and increased survival in a rat model.2 A very useful tool for probing the involvement of NO in physiological processes.3,4
Biochemicals & reagents
148819-94-7
Carboxy-PTIO; c-PTIO
Akaike et al. (1993), Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor/.NO through a radical reaction, Biochemistry, 32 827 Yoshida et al. (1994), Therapeutic effects of imidazolineoxyl N-oxide against endotoxin shock through its direct nitric oxide-scavenging activity; Biochem. Biophys. Res. Commun., 202 923 Hada et al. (2019), Nitric Oxide Is Involved in Heavy Ion-Induced Non-Targeted Effects in Human Fibroblasts; Int. J. Mol. Sci., 20 4327 Jin et al. (2020), A novel quinolinylmethyl substituted ethylenediamine compound exerts anti-cancer effects via stimulating the accumulation of reactive oxygen species and NO in hepatocellular carcinoma cells; Eur. J. Pharmacol., 885 173497
RT
PATHWAY: Redox -- RESEARCH AREA: Oxidative stress -- DISEASE AREA: Kidney disease