MIF antagonist / Antagonist of macrophage migration inhibitory factor (MIF, a pro-inflammatory cytokine). Displays anti-inflammatory activity. Increases survival in severe sepsis1. Inhibits airway remodeling in mouse asthma model2. Blocks MIF-induced autophagy3. Active in cellular and mouse models.
Biochemicals & reagents
478336-92-4
1) Al-Abed et al. (2005), ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis; J. Biol. Chem., 280 / 2) Chen et al. (2010), ISO-1, a macrophage migration inhibitory factor antagonist, inhibits airway remodeling in a murine model of chronic asthma; Mol. Med., 16 400 / 3) Chuang et al. (2012), Macrophage migration inhibitory factor induces autophagy via reactive oxygen species generation; PLoS One, 7 e37613
-20°C
PATHWAY: Cytokine; Autophagy; Cell migration -- RESEARCH AREA: Cell death; Neuroscience -- DISEASE AREA: Inflammation; Neurodegeneration