SRS16-86
Lipid peroxidation inhibitor / SRS16-86 is a third generation ferrostatin derivative with greater metabolic and plasma stability for in vivo studies. It protected mice in a renal severe ischemia-reperfusion injury model via inhibition of ferroptosis.1 SRS16-86 enhanced functional recovery after spinal cord injury in a rat model via upregulation of GPX4, GSH, and xCT as well as downregulation of lipid peroxidation marker 4-hydroxynonenal.2
Biochemicals & reagents
1793052-96-6
1. Linkermann et al. (2014), Synchronized renal tubular cell death involves ferroptosis; Proc. Natl. Acad. Sci. USA. 111 16841 2. Zhang et al. (2019), Ferroptosis inhibitor SRS 16-86 attenuates ferroptosis and promotes functional recovery in contusion spinal cord injury; Brain Res. 1706 48
-20°C
PATHWAY: Ferroptosis; Lipid signaling; Redox -- RESEARCH AREA: Cell death; Oxidative stress; Neuroscience -- DISEASE AREA: Inflammation; Ischemia