iFSP1
FSP1 inhibitor / iFSP1 inhibits ferroptosis suppressor protein 1, inducing ferroptosis.1 iFSP1 synergizes with GPX4 inhibitors to initiate ferroptosis in cancer cells.1 It potently induced ferroptosis, which promoted innate and adaptive anti-tumor immune responses, in human hepatocellular carcinoma cells which overexpress FSP1.2 A useful tool for establishing ferroptotic cells in Alzheimer’s disease models.3
Biochemicals & reagents
150651-39-1
1 Doll et al. (2019), FSP1 is a glutathione-independent ferroptosis suppressor; Nature 575 693 2 Cheu et al. (2023), Ferroptosis Suppressor Protein 1 Inhibition Promotes Tumor Ferroptosis and Anti-tumor Immune Responses in Liver Cancer; Cell Mol. Gastroenterol. Hepatol. 16 133 3 Yong et al. (2024), Penthorum chinense Pursh inhibits ferroptosis in cellular and Caenorhabditis elegans models of Alzheimer’s disease; Phytomedicine 127 155463
-20°C
PATHWAY: Ferroptosis -- RESEARCH AREA: Immunology; Cell death -- DISEASE AREA: Cancer; Neurodegeneration