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Nobiletin

Supplier:
Catalogue number:
10-4763-02
Size:
50 mg
Product is available in:
  • USA
  • Canada
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Attenuates metabolic syndrome / Nobiletin is a natural product isolated from citrus peels. It has recently been shown to possess circadian clock amplitude-enhancing properties and was able to prevent metabolic syndrome in mice via a Clock gene-dependent mechanism.1 Nobiletin directly bound to and activated RORα/γ. Nobiletin has previously been shown to attenuate the effects of metabolic syndrome2, have anti-neuroinflammatory effects3, possess neurotrophic activity4, and be a cancer chemopreventative agent5.

Product Type:

Biochemicals & reagents

CAS Number:

478-01-3

Reference:

1) He et al. (2016), The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome; Cell Metabolism, 23 610 2) Mulvihill et al. (2011), Nobiletin attenuates VLDL overproduction, dyslipidemia, and atherosclerosis in mice with diet-induced insulin resistance; Diabetes 60 1446 3) Cui et al. (2010), Anti-neuroinflammatory activity of nobiletin on suppression of microglial activation; Biol.Pharm.Bull., 33 1814 4) Nagase et al. (2005), Mechanism of neurotrophic action of nobiletin in PC12D cells; Biochemistry 44 13683 5) Walle (2007), Methoxylated flavones,a superior cancer chemopreventative flavonoid subclass?; Semin.Cancer Biol. 17 354

Storage Temperature:

RT

Additional Information:

PATHWAY: Fatty acid metabolism; Transcription -- RESEARCH AREA: Circadian clock; Neuroscience; Oxidative stress -- DISEASE AREA: Cancer; ObesityDiabetes; Inflammation