Ochratoxin A
Mycotoxin / Ochratoxin A is a mycotoxin that causes widespread contamination in foodstuffs and environments thus causing health risks to humans and animals.1 It has been shown to be carcinogenic2, mutagenic3, neurotoxic4, nephrotoxic5 and immunotoxic1. It increases lipid peroxide levels in cells6 and reduces antioxidant defenses2 leading to oxidative DNA damage3.
Biochemicals & reagents
303-47-9
NSC-201422; NSC-221991
1 Al-Anati and Petzinger (2006); Immunotoxic activity of ochratoxin A, J. Vet. Pharmacol. Ther., 29 79 2 Cavin et al. (2007); Reduction in antioxidant defenses may contribute to ochratoxin A toxicity and carcinogenicity, Toxicol. Sci., 96 30 3 Palma et al. (2007); Ochratoxin A-Induced Mutagenesis in Mammalian Cells Is Consistent with the Production of Oxidative Stress, Chem. Res. Toxicol., 20 1031 4 Sava et al. (2006); Acute neurotoxic effects of the fungal metabolite ochratoxin A, Neurotoxicology, 27 82 5 Khoi et al. (2021); Ochratoxin A-Induced Nephrotoxicity: Up-to-Date Evidence, Int. J. Mol. Sci., 22 11237 6 Petrik et al. (2003); Apoptosis and oxidative stress induced by ochratoxin A in rat kidney, Arch. Toxicol., 77 685
-20°C
PATHWAY: DNA damage -- RESEARCH AREA: Oxidative stress; Neuroscience; Immunology -- DISEASE AREA: Cancer