Lipofermata
Fatty acid transport protein 2 (FATP2) inhibitor / Lipofermata is an inhibitor of fatty acid transport protein 2 (FATP2; IC50 = 4.84 µM).1 It does not inhibit glucose transport or the activity of long chain acyl-CoA synthetase. It prevented palmitate-mediated oxidative stress, induction of BiP and CHOP, and cell death in a dose-dependent manner in hsHepG2 and mINS-1E cells suggesting utility in preventing fatty acid-mediated cell death pathways and lipotoxic disease.2 Inhibition was specific for long and very long chain fatty acids but not medium (C6-C10) acids. Lipofermata abrogates lipid transport into melanoma cells and reduces melanoma growth and invasion.3
Biochemicals & reagents
297180-15-5
CB16.2
1) Sandoval et al. (2010), Identification and characterization of small compound inhibitors of human FATP2; Biochem. Pharmacol. 79 990 2) Ahowesso et al. (2015), Chemical inhibition of fatty acid absorption and cellular uptake limits lipotoxic cell death; Biochem. Pharmacol. 98 167 3) Zhang et al. (2018), Adipocyte-derived lipids mediate melanoma progression via FATP proteins; Cancer Discov. 8 1006
-20°C
PATHWAY: Fatty acid metabolism -- RESEARCH AREA: Oxidative stress; Cell death -- DISEASE AREA: Cancer