Fumarate hydratase-IN-1
Supplier:
Catalogue number:
10-4578-01
Size:
5 mg
Product is available in:
Fumarate hydratase inhibitor / Fumarate hydratase-IN-1 is a pro-drug inhibitor of fumarate hydratase, an important enzyme in the tricarboxylic acid (TCA) cycle. This cell permeable compound is converted to the active carboxylic acid by intracellular esterases (Ki = 4.5 µM for free acid). The ethyl ester displayed cell-growth inhibitory activity against several cancer lines under nutrient (glucose) deprived conditions with an average IC50 = 2.2 µM.
Product Type:
Biochemicals & reagents
CAS Number:
1644060-37-6
Reference:
1) Takeuchi et al. (2015), Identification of Fumarate Hydratase Inhibitors with Nutrient-Dependent Cytotoxicity; J. Am. Soc. Chem. 137 564
Storage Temperature:
-20°C
Additional Information:
PATHWAY: Proliferation; Mitochondrial function -- DISEASE AREA: Cancer