YM-155
Survivin inhibitor / A novel small molecule survivin suppressant. YM-155 suppresses expression of survivin (a member of the IAP family) and induced apoptosis in human tumor cell lines at 10 nmol/L with little effect on other IAP or Bcl-2 family members.1 Overcomes erlotinib resistance in EGFR mutation-positive non-small cell lung cancer.2 Induces DNA damage.3 Induces an autophagy-dependent cell death in adenoid cystic carcinoma cells.4
Biochemicals & reagents
781661-94-7
Sepantronium bromide
1) Nakahara et al. (2007), YM155, a novel small-molecule surviving suppressant, induces regression of established human hormone-refractory prostate tumor xenografts; Cancer Res. 67 8014 2) Okamoto et al. (2012), Overcoming erlotinib resistance in EGFR mutation-positive non-small cell lung cancer cells by targeting survivin; Mol.Cancer Ther. 11 204 3) Glaros et al. (2012), The “survivin suppressants” NSC 80467 and YM 155 induce a DNA damage response; Cancer Chemother.Pharmacol. 70 207Wang et al. (2014), Induction of autophagy-dependent cell death by the survivin suppressant YM155 in salivary adenoid cystic carcinoma; Apoptosis 19 748
-20°C
PATHWAY: DNA repair; Apoptosis inducer; Autophagy -- RESEARCH AREA: Cell death -- DISEASE AREA: Cancer