Destruxin B
Apoptosis inducer; anticancer agent / A cyclic depsipeptide produced by various species of fungi.1 Induces apoptosis in human nonsmall cell lung cancer cells.2 Displays selective cytotoxic effects on human oral cancer cell lines.3 Inhibits hepatocellular carcinoma cell growth via modulation of the Wnt/β-catenin pathway.4
Biochemicals & reagents
2503-26-6
Fermentation product produced by Metarrhizium anisopliae
1) Pedras et al. (2002), The destruxins: synthesis, biosynthesis, biotransformation, and biological activity; Phytochemistry, 59 579 2) Wu et al. (2013), Destruxin B Isolated from Entomopathogenic Fungus Metarhizium anisopliae Induces Apoptosis via a Bcl-2 Family-Dependent Mitochondrial Pathway in Human Nonsmall Cell Lung Cancer Cells; Evid. Based Complement. Alternat. Med,, 2013 548929 3) Liu et al. (2014), Selective apoptotic cell death effects of oral cancer cells treated with destruxin B; BMC Complement. Altern. Med., 14 207 4) Liu et al. (2014), Destruxin B inhibits hepatocellular carcinoma cell growth through modulation of the Wnt/β catenin signaling pathway and epithelial-mesenchymal transition; Toxicol. In Vitro, 28 552
-20°C
PATHWAY: Apoptosis inducer; Wnt; Cytotoxicity -- RESEARCH AREA: Cell death -- DISEASE AREA: Cancer