Fatostatin
SREBP activation inhibitor / Blocks adipogenesis by inhibiting the activation of SREBP. Inhibits the ER-Golgi translocation of SREBPs via binding to their escort protein (SCAP). Prevents increases in body weight, blood glucose and hepatic fat accumulation in obese ob/ob mice1. Inhibits high glucose-induced TGF-β in mesangial cells2. Cell permeable.
Biochemicals & reagents
125256-00-0
1) Kamisuki et al. (2009), A small molecule that blocks fat synthesis by inhibiting the activation of SREBP; Chem. Biol., 16 882 2) Uttarwar et al. (2012), SREBP-1 activation by glucose mediates TGF-β upregulation in mesangial cells; Am. J. Physiol. Renal Physiol., 302 F329
RT
TARGET: Transcription factor -- PATHWAY: Transcription; Fatty acid metabolism; Lipid signaling; Apoptosis inducer; Cytokine -- RESEARCH AREA: Cell death -- DISEASE AREA: Obesity; CancerDiabetes; Inflammation