Pifithrin α
p53 inhibitor / Pifithrin α (63208-82-2) is a reversible inhibitor of p53-mediated transcription and p53-dependent apoptosis. Enhances survival after genotoxic stress and protects against chemotherapeutic side-effects in mice.1,2 Supresses self-renewal of embryonic stem cells.5 Pfithrin α protects against neuronal death in models of stroke and neurodegenerative disease.3 AhR agonist.4
Biochemicals & reagents
63208-82-2
PFT-α
1) Komarov et al. (1999), A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy; Science, 285 1733 2) Komarova and Gudkov et al. (2000), Suppression of p53: a new approach to overcome the side effects of antitumor therapy; Biochemistrry., 65 41 3) Culmsee et al. (2001), A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid-peptide; J. Neurochem., 77 220 4) Hoagland et al. (2005), The p53 inhibitor pifithrin-α is a potent agonist of the aryl hydrocarbon receptor; J. Pharmacol. Exp. Ther., 314 630 5) Abdelalim and Tooyama (2012), The p53 inhibitor, pifithrin-α, suppresses self-renewal of embryonic stem cells; Biochem. Biophys. Res. Comm., 420 605
-20°C
TARGET: Transcription factor -- PATHWAY: p53; Apoptosis inhibitor; Transcription; Autophagy -- RESEARCH AREA: Stem cells; Cell death; Neuroscience -- DISEASE AREA: Neurodegeneration; DiabetesIschemia