SR-9009
RevErbα/β agonist / Agonist at nuclear receptor Rev-ErbA1. Greatly diminishes VILI-induced lung edema, inflammatory cell infiltration and TNFα production in a rat lung injury model2. Suppresses atherosclerosis in a mouse model3.
Biochemicals & reagents
1379686-30-2
1) Solt et al. (2012) Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists; Nature 485 62 2) Li et al. (2014) A study on circadian rhythm disorder of rat lung tissue caused by mechanical ventilation induced lung injury; Int.Immunopharmacol. 18 249 3) Sitaula et al. (2015) Suppression of atherosclerosis by synthetic REV-ERB agonist; Biochem.Biophys.Res.Commun. 460 566
-20°C
TARGET: Transcription factor -- PATHWAY: Transcription; Fatty acid metabolism -- RESEARCH AREA: Circadian clock -- DISEASE AREA: Atherosclerosis; InflammationObesity