Napabucasin
STAT3 inhibitor / Cancer cell stemness inhibitor / Inhibits gene transcription driven by STAT3. Inhibits cancer cell stemness gene expression and blocks spherogenesis of stemness-high cancer cells isolated from a variety of cancer types.1 Effective antitumor agent as a monotherapy or in combination with other agents such as taxol in mouse models.2 Clinical trials have demonstrated encouraging anti-tumor activity with the potential to suppress metastasis and prevent relapse in patients with various types of cancer.2,3 Overcomes cisplatin resistance in non-small cell lung cancer.4
Biochemicals & reagents
83280-65-3
BBI608
1) Li et al. (2015), Suppression of cancer relapse and metastasis by inhibiting cancer stemness; Proc. Natl. Acad. Sci. USA, 112 1839 2) Hubbard and Grothey (2017), Napabucasin: an Update on the First-in-Class Cancer Stemmness Inhibitor; Drugs, 77 1091 3) Zhang et al. (2016), Suppression of prostate cancer progression by cancer cell stemness inhibitor napabucasin; Cancer Med., 5 1251 4) MacDonagh et al. (2018), BBI608 inhibits cancer stemness and reverses cisplatin resistance in NSCLC; Cancer Lett., 428 117
-20°C
TARGET: Transcription factor -- PATHWAY: JAK/STAT; Transcription -- RESEARCH AREA: Cancer Stem Cells -- DISEASE AREA: Cancer