7alpha-Hydroxycholesterol
Bile acid precursor / Metabolite resulting from the action of cholesterol 7 alpha-hydroxylase on cholesterol. 7α-Hydroxycholesterol is the first intermediate and a rate-limiting step in the major pathway for bile acid synthesis in humans. A pro-inflammatory mediator which upregulates production of CCL2 and MMP9 in macrophages and may promote progression of atherosclerosis.2,3 Possible biomarker for cellular lipid peroxidation.4
Biochemicals & reagents
566-26-7
1) Duane and Javitt (2002), Conversion of 7 alpha-hydroxycholesterol to bile acid in human subjects: is there an alternate pathway favoring cholic acid synthesis?; J. Lab. Clin. Med., 139 109 2) Kim et al. (2015) 7α-Hydroxycholesterol induces inflammation by enhancing production of chemokine (C-C motif) ligand 2; Biochem. Biophys. Res. Commun., 467 879 3) Kim et al. (2014) 27-Hydroxycholesterol and 7alpha-hydroxycholesterol trigger a sequence of events leading to migration of CCR5-expressing Th1 lymphocytes; Toxicol. Appl. Pharmacol., 274 462 4) Saito and Noguchi (2014) 7-Hydroxycholesterol as a possible biomarker of cellular lipid peroxidation: difference between cellular and plasma lipid peroxidation; Biochem. Biophys. Res. Commun., 446 741
-20°C
TARGET: TLR (Toll-like receptor) -- PATHWAY: Cholesterol metabolism; Fatty acid metabolism; Cytokine; TLR signaling -- DISEASE AREA: Inflammation; Atherosclerosis