Loxoribine
TLR7 agonist / Toll-like receptor 7 (TLR7) agonist.1 A potent immunostimulant with a relatively broad spectrum of immunobiological activities including upregulation of the activity of B cells, T cells, NK cells, macrophages and LAK cells.2 Induces secretion of IFN- by NK cells.3 Inhibits influenza A infection in chickens.4 Induces tumor regression by reversing Treg-induced immunosuppression.5
Biochemicals & reagents
121288-39-9
RWJ-21757
1) Heil et al. (2003), The Tool-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily; Eur. J. Immunol., 33 2987 2) Goodman et al. (1995), A new approach to vaccine adjuvants. Immunopotentiation by intracellular T-helper-like signals transmitted by loxoribine Pharm. Biotechnol., 6 581 3) Girart et al. (2007), Engagement of TLR3, TLR7 and NKG2D regulate IFN-gamma secretion but not NKG2D-mediated cytotoxicy by human NK cells stimulated with suboptimal doses of IL-12; J. Immunol., 179 3472 4) Stewart et al. (2012), Toll-like receptor 7 ligands inhibit influenza A infection in chickens; J. Interferon Cytokine Res,, 32 46 5) Wang et al. (2015), The TLR7 agonist induces tumor regression both by promoting CD4-T cells proliferation and by reversing T regulatory cell-mediated suppression via dendritic cells; Oncotarget, 6 1779
-20°C
TARGET: TLR (Toll-like receptor) -- PATHWAY: TLR signaling; Cytokine -- RESEARCH AREA: Immunology -- DISEASE AREA: Cancer; Infectious disease