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Tubastatin A · HCl

Supplier:
Catalogue number:
10-4530-02
Size:
25 mg
Product is available in:
  • USA
  • Canada
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HDAC-6 inhibitor / Tubastatin A is a potent and highly selective inhibitor of HDAC6 (IC50 = 15 nM, >1000-fold selectivity against other HDAC isoforms, approx. 60-fold versus HDAC8).1 It displayed anti-inflammatory and anti-rheumatic effects in Freund’s competitive adjuvant induced animal model of inflammation.2 Tubastatin A inhibited TNF-α (IC50 = 272 nM) and IL-6 (IC50 = 712 nM) in LPS stimulated human THP-1 macrophages.2 Tubastatin A has also been shown to have therapeutic potential for treatment of Alzheimers disease via altered amloid-β load and reduced tau hyperphosphorylation.3,4,5

Product Type:

Biochemicals & reagents

CAS Number:

1310693-92-5

Reference:

1) Butler et al. (2010), Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A; J.Am.Chem.Soc. 132 10842 2) Vishwakarma et al. (2013), Tubastatin, a selective histone deacetylase 6 inhibitor shows anti-inflammatory and anti-rheumatic effects; Int.Immunopharmacol, 16 72 3) Noack and Richter-Landsberg (2014), HDAC6 inhibition results in tau acetylation and modulates tau phosphorylation and degradation in oligodendrocytes; Glia, 62 535 4) Selenica et al. (2014), Histone deacetylase 6 inhibition improves memory and reduces total tau levels in a mouse model of tau deposition; Alzheimers Res.Ther. 6 12 5) Zhang et al. (2014) Tubastatin A/ACY-1215 improves cognition in Alzheimers disease transgenic mice; J.Alzheimers Dis. 41 1193

Storage Temperature:

-20°C

Additional Information:

TARGET: Protein deacetylase -- PATHWAY: Chromatin; Posttranslational modification -- RESEARCH AREA: Epigenetics; Neuroscience -- DISEASE AREA: Inflammation; Neurodegeneration