MMP inhibitor (pan spec.) / Potent pan-specific inhibitor of matrix metalloproteinases ( MMP3 Ki=0.013 µM). Inhibits MMP-1, -2, -7-10, -12-14 and MMP-20. Attenuates inflammation-induced thermal hyperalgesia. Cell Permeable.
Biochemicals & reagents
161314-17-6
1) MacPherson et al. (1997), Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits ; J. Med Chem, 40 2525 / 2) Jeng et al. (1998), Sulfonamide-based hydroxamic acids as potent inhibitors of mouse macrophage metalloelastase ; Bioorg. Med. Chem. Lett., 8 897 / Christianson et al. (2012), Spinal matrix metalloproteinase 3 mediates inflammatory hyperalgesia via a tumor necrosis factor-dependent mechanism ; J. Neuroscience, 200 199
RT
TARGET: Protease -- PATHWAY: TNF -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Inflammation; Neurodegeneration