Ornithine decarboxylase inhibitor / Pyridoxal 5’-phosphate – dependent ornithine decarboxylase (ODC) is a key enzyme involved in polyamine synthesis and a potential cancer drug target. POB is a transition state-based, cell permeable pro-drug inhibitor of ODC. Intracellularly, POB is phosphorylated by pyridoxal kinase and the methyl ester hydrolyzed. This active inhibitor most likely binds apo-ODC resulting in greatly reduced ODC activity and inhibition of cellular proliferation. POB was able to inhibit proliferation in a wide variety of tumor cell lines: LN229 (IC50 = 50 µM), Jurkat, COS7, SW2 and both high and low-grade glioblastoma multiforme. More potent than DFMO.
Biochemicals & reagents
946135-39-3
1) Wu et al., (2007), New transition state-based inhibitor for human ornithine decarboxylase inhibits growth of tumor cells; Mol. Cancer Ther.. 6 1831 2) Wu et al., (2011), A novel approach to inhibit intracellular vitamin B6-dependent enzymes: proof of principle with human and plasmodium ornithine decarboxylase and human histidine decarboxylase; FASEB J. 25 2109
RT
TARGET: Polyamine -- PATHWAY: Proliferation -- DISEASE AREA: Cancer