MK-886
FLAP inhibitor / Inhibitor of leukotriene biosynthesis(IC50 = 2.5 nM in human PMN)1 via 5-lipoxygenase-activating protein (FLAP) inhibition (IC50 = 30 nM)2. Also inhibits PPARα (80% inhibition at 10 µM).3
Biochemicals & reagents
118414-82-7
L-663,536
1) Gillard et al (1989) L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor. Can.J.Physiol.Pharmacol. 67 456 / 2) Evans et al (1991) 5-Lipoxygenase-activating protein is the target of a quinoline class of leukotriene synthesis inhibitors Mol.Pharmacol. 40 22 / 3) Kehrer et al (2001) Inhibition of peroxisome-proliferator-activated receptor (PPAR)α by MK886. Biochem.J. 356 899
RT
TARGET: PPAR -- PATHWAY: Lipid signaling; PPAR; Transcription; Coagulation; Calcium signaling -- RESEARCH AREA: Immunology -- DISEASE AREA: Inflammation