Difluoromethylornithine HCl
Polyamine biosynthesis inhibitor / Difluoromethylornithine HCl (96020-91-6) is a selective inhibitor of ornithine decarboxylase1. Induces apoptosis in a variety of cells2. Difluoromethylornithine HCl displays cancer chemopreventive activity3. Cell permeable. Active in vivo.
Biochemicals & reagents
96020-91-6
DFMO; Eflornithine
1) Verma et al. (1990), Inhibition of tumor promotion by DL-alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase; Basic Life Sci., 52 195 / 2) Takahashi et al. (2000), alpha-difluoromethylornithine induces apoptosis as well as anti-angiogenesis in the inhibition of tumor growth and metastasis in a human gastric cancer model; Int. J. Cancer, 85 243 / 3) Meyskens et al. (1999), Development of difluoromethylornithine (DFMO) as a chemoprevention agent; Clin. Cancer Res., 5 945
RT
TARGET: Polyamine -- PATHWAY: Apoptosis inducer -- RESEARCH AREA: Cell death -- DISEASE AREA: Cancer