m-3M3FBS
Phospholipase C activator / Activator of phospholipase C (PLC). Stimulates superoxide generation, Ca2+ release and inositol phosphate release in a variety of cell types1. Inhibits growth of U937 and THP-1 cells2. Also affects calcium homeostasis independently of PLC activation3.
Biochemicals & reagents
200933-14-8
1) Bae et al. (2003), Identification of a compound that directly stimulates phospholipase C activity; Mol. Pharmacol., 63 1043 2) Lee et al. (2005), The novel phospholipase C activator, m-3M3FBS, induces monocytic leukemia cell apoptosis; Cancer Lett., 222 227 3) Krjukova et al. (2004), Phospholipase C activator m-3M3FBS affects Ca2+ homeostasis independently of phospholipase C activation; Br. J. Pharmacol., 143 3
-20°C
TARGET: Phospholipase -- PATHWAY: Calcium signaling; Lipid signaling -- RESEARCH AREA: Oxidative stress