ONO-RS-082
Phospholipase A2 inhibitor / Reversible inhibitor of Ca2+-independent phospholipase A2 (PLA2), IC50=7 uM for guinea pig lung PLA2.1 Inhibits epinephrine-induced thromboxane production in platelets.1 Inhibition of PLA2 by ONO-RS-032 disrupts endosome tubule formation and maintenance of the Golgi complex.2-4 Prevents Xenopus oocyte maturation at stage V.5
Biochemicals & reagents
99754-06-0
PACA
1) Banga et al. (1986), Activation of phospholipases A and C in human platelets exposed to epinephrine: role of glycoproteins IIb/IIIa and dual role of epinephrine; Proc.Natl.Acad.Sci.USA 83 9197 2) De Figueiredo et al. (2001), Inhibition of transferrin recycling and endosome tubulation by phospholipase A2 antagonists; J.Biol.Chem. 276 47361 3) Schmidt et al. (2010), A role for phospholipase A2 activity in membrane tubule formation and TGN trafficking; Traffic 11 1530 4) Bechler and Brown (2014), G?1?2 activates phospholipase A2-dependent Golgi membrane tubule formation; Front.Cell.Dev.Biol. 28 0004 5) Islam et al. (2005), The distinct stage-specific effects of 2-(p-amylcinnamoyl)amino-4-chlorobenzoic acid on the activation of MAP kinase and Cdc2 kinase in Xenopus oocyte maturation; Cell Signal. 17 507
-20°C
TARGET: Phospholipase -- PATHWAY: Lipid signaling; Coagulation; Intracellular transport -- RESEARCH AREA: Vesicles -- DISEASE AREA: Diabetes; Infectious diseaseHypertension