U-73122
PLC inhibitor / Inhibits receptor-coupled phospholipase C-dependent processes in platelets and neutrophils via interfering with G protein-PLC interaction1. A useful tool for probing the involvement of PI-PLC in receptor mediated cellular physiology and processes2-4. Cell permeable.
Biochemicals & reagents
112648-68-7
1) Bleasdale et al., (1990), Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils; J. Pharmacol. Exp. Ther. 255 756 2) Zholos et al., (2004), Phospholipase C, but not InsP3 or DAG,-dependent activation of the muscarinic receptor-operated cation current in guinea-pig ileal smooth muscle cells; Br. J. Pharmacol. 141 23 3) Jun et al., (2004), Diacylglycerol and its formation by phospholipase C regulate Rab- and SNARE dependent yeast vacuole fusion; J. Biol. Chem. 279 53186 4) Fernandez-Ulibarri et al., (2007), Diacylglycerol is required for the formation of COPI vesicles in the Golgi-to-ER transport pathway; Mol. Biol. Cell 18 3250
RT
TARGET: Phospholipase -- PATHWAY: Coagulation; Calcium signaling; Lipid signaling; Apoptosis inhibitor; Carbohydrate metabolism; Mitochondrial function -- RESEARCH AREA: Cell death -- DISEASE AREA: Diabetes