iNOS inhibitor / Potent, tight-binding, slow inhibitor of inducible nitric oxide synthase (iNOS). Highly selective for iNOS3 (Ki = 7 nM) over nNOS or eNOS (Ki’s of 2 µM and 50 µM respectively).1 Cell permeable and active in vivo.2
Biochemicals & reagents
214358-33-5
1) Garvey et al. (1997), 1400W is a slow, tight-binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo; J. Biol. Chem., 272 4959 2) Thomsen et al. (1997), Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: Studies with 1400W, a novel inhibitor; Cancer Res., 57 3300 3) Pigott et al. (2013), On the selectivity of neuronal NOS inhibitors; Br. J. Pharmacol., 168 1255
-20°C
TARGET: NOS (Nitric oxide synthase) -- PATHWAY: Redox