TRIM
Nitric oxide synthase inhibitor / A potent inhibitor of neuronal and inducible nitric oxide synthases, (IC50 = 28.2 and 27.0 μM respectively). Inhibits endothelial NOS with lower potency (IC50 = 1057.5 μM1. Displays antinociceptive activity in vivo2.
Biochemicals & reagents
25371-96-4
1) Handy et al. (1995), The antinociceptive effect of 1-(2-trifluoromethylphenyl)imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse; Br. J. Pharmacol., 116 2349 2) Handy et al. (1996), Inhibition of nitric oxide synthase by 1-(2-trifluoromethylphenyl) imidazole (TRIM) in vitro: antinociceptive and cardiovascular effects; Br. J. Pharmacol., 119 423
RT
TARGET: NOS (Nitric oxide synthase) -- PATHWAY: Redox -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Pain