Diphenylene iodonium chloride
Flavoprotein inhibitor / An irreversible inhibitor of iNOS and eNOS (IC50s=50 and 100 nM respectively.1 Binds to and inhibits the flavoprotein of neutrophil NADPH oxidase.2 Novel agonist for GPR3.3 Inhibits NFκB activation induced by IL-1β.4 Prevents early alcohol-induced liver injury in rodent models.5
Biochemicals & reagents
4673-26-1
DPI
1) Stuehr et al. (1991), Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs; FASEB J., 5 98 2) Yea et al. (1990), Purification and some properties of the 45 kDa diphenylene iodonium-binding flavoprotein of neutrophil NADPH oxidase; Biochem. J., 265 95 3) Ye et al. (2014), Identification of a novel small-molecule agonist for human G protein=coupled receptor 3; J. Pharmacol. Exp. Ther., 349 437 4) Mendes et al. (2001), Diphenyleneiodonium inhibits NF-kappaB activation and iNOS expression induced by IL-1beta: involvement of reactive oxygen species; Mediators Inflamm., 10 209 5) Kono et al. (2001), Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat; Am. J. Physiol. Gastrointest. Liver Physiol., 280 G1005
-20°C
TARGET: NOS (Nitric oxide synthase) -- PATHWAY: Redox; Cytokine; NFkappaB -- RESEARCH AREA: Oxidative stress -- DISEASE AREA: Liver disease; Inflammation