Smer-28
Autophagy inducer / Induces autophagy via an mTOR-independent pathway. Enhances clearance of β-amyloid protein in cell lines and primary neuronal culture models.1-3 May be a useful lead compound for the development of new therapeutics for neurodegenerative diseases.4 Induces the release of articular cartilage vesicles from healthy articular chondrocytes in a dose- and time-dependent manner.5 Promotes reprogramming of fibroblasts to neural stem-like cells.6 Cell permeable..
Biochemicals & reagents
307538-42-7
1) Tian et al. (2011), A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway; FASEB J., 25 1934 2) Tian et al. (2014), the convergence of endosomal and autophagosomal pathways; implications for APP-CTF degradation; Autophagy, 10 694 3) Shen et al. (2011), Novel cell- and tissue-based assays for detecting misfolded and aggregated protein accumulation within aggresomes and inclusion bodies; Cell Biochem. Biophys., 60 173 4) Renna et al. (2010), chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases; J. Biol. Chem., 285 11061 5) Rosenthal et al. (2015), Autophagy modulates articular cartilage vesicle formation in primary articular chondrocytes; J. Biol. Chem., 290 13028 6) Zhang et al. (2016), Phamracological Reprogramming of Fibroblasts into Neural Stem Cells by Signaling-Directed Transcriptional Activation; Cell Stem Cell., 18 653
RT
TARGET: Kinase -- PATHWAY: mTOR; Autophagy; PI3K -- RESEARCH AREA: Cell death; Stem cells; Vesicles; Ubiquitin/Proteasome -- DISEASE AREA: Neurodegeneration