LM22A-4
TrkB agonist / Small molecule BDNF mimetic displaying neurotrophhic activity. Partial agonist at TRKB and activates TRKB signaling. In in vitro models of neurodegenerative disease, it prevented neuronal degeneration with equal efficacy to that of BDNF. After in vivo administraton, it caused hippocampal and striatal TrkB activation in mice and improved motor learning after traumatic brain injury in rats1. Improves respiratory function in a mouse models of Rett syndrome2.
Biochemicals & reagents
37988-18-4
1) Massa et al. (2010), Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents; J. Clin. Invest., 120 1774 2) Schmid et al. (2012), A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome; J. Neurosci., 32 1803
-20°C
TARGET: Kinase -- PATHWAY: Neurotrophin -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Neurodegeneration