Calphostin C
Protein Kinase C inhibitor / Potent and specific inhibitor of protein kinase C (PKC, IC50 = 50 nM).1 Inhibition of PKC is light dependent2 and is competitive with the diacylglycerol / phorbol ester binding site1. Calphostin C competes with the diacylglycerol / phorbol ester binding site in other proteins such as Munc13-1.3 Reverses oxycodone-induced tolerance to respiratory depression.4
Biochemicals & reagents
121263-19-2
UCN-1028C; PKF115-584
1 Kobayashi et al. (1989), Calphostin C (UNC-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C; Biochem. Biophys. Res. Commun. 159 548 2 Bruns et al. (1991), Inhibition of protein kinase C by calphostin C is light-dependent; Biophys. Res. Commun. 176 288 3 Betz et al. (1998), Munc13-1 is a presynaptic phorbol ester receptor that enhances neurotransmitter release; Neuron 21 123 4 Hill et al. (2018), Oxycodone-induced tolerance to respiratory depression: reversal by ethanol, pregabalin and protein kinase C inhibition; Br. J. Pharmacol. 175 2492
-20°C
TARGET: Kinase -- DISEASE AREA: Mood disorders