TUDCA
ER stress inhibitor / A classic inhibitor of endoplasmic reticulum (ER) stress.1 Reduces ER stress and adipose tissue inflammation in a mouse model of high fat diet-induced obesity.2 Blocks ER stress-induced NLRP3 inflammasome activation and hepatocyte death.3 Attenuates amyloid precursor protein processing and amyloid-β deposition in APP/PS1 mouse model.4
Biochemicals & reagents
14605-22-2
Tauroursodeoxycholic acid, sodium salt
1) Xie et al. (2002), Effects of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation; Hepatology, 36 592 2) Chen et al. (2016), chemical chaperones reduce ER stress and adipose tissue inflammation in high fat diet-induced mouse model of obesity; Sco. Rep., 6 27486 3) Lebeaupin et al. (2015), ER stress induces NLRP3 inflammasome activation and hepatocyte death; Cell Death Dis., 6 e1879 4) Nunes et al. (2012), TUDCA, a bile acid, attenuates amyloid precursor protein processing and amyloid-β deposition in APP/PS1 mice; Mol. Neurobiol. 45 440
-20°C
TARGET: Inflammasome; UPR (Unfolded Protein Response) -- PATHWAY: Cholesterol metabolism; Autophagy -- RESEARCH AREA: Cellular stress; Cell death; Neuroscience -- DISEASE AREA: Obesity; InflammationNeurodegeneration