Salubrinal
eIF2α Phosphatase inhibitor / Endoplasmic reticulum (ER) stress inhibitor. Salubrinal is a selective inhibitor of cellular complexes that dephosphorylate eukaryotic initiation factor 2 subunit alpha (eIF2α).1 It has been found to interact with the anti-apoptotic protein Bcl-2 offering protection from the apoptotic and autophagic effects that result from loss of Bcl-2 function.2 Salubrinal blocked NFATc1 expression and osteoclast differentiation by RANKL via phosphorylation of eLF2α resulting in a decrease of global protein synthesis. It efficiently blocked osteoporosis in a mouse model treated with RANKL.3
Biochemicals & reagents
405060-95-9
1) Boyce et al. (2005) A selective inhibitor of eIF2α dephosphorylation protects cells from ER stress, Science 307 935 2) Kessel (2006) Protection of Bcl-2 by salubrinal Biochem.Biophys.Res.Commun. 346 1320 3) He et al. (2013) Osteoporosis regulation by salubrinal through eFI2α mediated differentiation of osteoclast and osteoblast Cell.Signal. 25 552
-20°C
TARGET: Phosphatase; UPR (Unfolded Protein Response) -- PATHWAY: Apoptosis inhibitor; Autophagy; Protein synthesis -- RESEARCH AREA: Cellular stress; Cell death -- DISEASE AREA: Osteoporosis