Azoramide
UPR modulator / Azoramide is a modulator of the unfolded protein response (UPR).1 It improves endoplasmic reticulum (ER) protein folding and activates ER chaperone capacity to protect cells against ER stress. It displayed potent anti-diabetic activity in two mouse models by improving insulin sensitivity and pancreatic β cell function. Azoramide increased SERCA expression leading to enhanced calcium retention in the ER indicating calcium homeostasis as a possible mechanism for its anti-diabetic acitivty.
Biochemicals & reagents
932986-18-0
1) Fu (2015), Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity; Sci. Transl. Med. 7 292ra98
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TARGET: ER/Golgi; UPR (Unfolded Protein Response) -- PATHWAY: Degradation; Calcium signaling -- RESEARCH AREA: Cellular stress; Neuroscience -- DISEASE AREA: Diabetes; Neurodegeneration