Cinnabarinic Acid
AhR ligand (endogenous) / A novel endogenous tryptophan metabolite which acts as an aryl hydrocarbon receptor (AHR) agonist1. It drives IL-22 production by stimulating the differentiation of human and mouse T cells producing IL-221. Induces apoptosis in thymocytes2. Activates type 4 metabotropic glutamate receptors3. Counteracts excitotoxic neuronal cell death induced by NMDA in mixed cultures of cortical cells. Displays neuroprotective activity3.
Biochemicals & reagents
606-59-7
Cinnabaric acid
1) Lowe et al. (2014), Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production PLoS One, 9(2) e87877 2) Hiramatsu et al. (2008), Cinnabarinic acid generated from 3-hydroxyanthranilic acid strongly induces apoptosis in thymosytes through the generation of reactive oxygen species and the induction of caspase; J. Cell. Biochem., 103 42 3) Fazio et al. (2012), Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors; Mol. Pharmacol., 81 643
-20°C
TARGET: Tryptophan; Transcription factor -- PATHWAY: Cytokine; Amino acid metabolism; Apoptosis inducer; Chromatin; Transcription -- RESEARCH AREA: Immunology; Neuroscience; Cell death; Oxidative stress -- DISEASE AREA: Neurodegeneration; Inflammation