Spastazoline
Supplier:
Catalogue number:
10-4240-01
Size:
5 mg
Product is available in:
Spastin inhibitor / Spastazoline is an ATP-competitive inhibitor (IC50 = 99 nM) of the microtubule-severing AAA protein spastin. It is selective against four related AAA proteins (XL-katarin, Hs-FIGL1, Mm-VCP, and Hs-PCH2). A new and interesting tool for the study of the assembly, disassembly, or maintenance of microtubule-based cellular structures.
Product Type:
Biochemicals & reagents
CAS Number:
2351882-11-4
Reference:
1) Cupido et al. (2019), Designing a chemical inhibitor for the AAA protein spastin using active site mutations; Nat. Chem. Biol. 15 444
Storage Temperature:
-20°C
Additional Information:
TARGET: Cytoskeleton; Lysosome -- PATHWAY: DNA damage; Intracellular transport -- RESEARCH AREA: Vesicles; Neuroscience -- DISEASE AREA: Neurodegeneration