Vinblastine sulfate
Microtubule depolymerizer / Semisynthetic alkaloidal anticancer agent. Induces cell cycle arrest at G2/M phase by inhibiting mitotic spindle formation1. Inhibits normal microtubule assembly and induces aberant tubulin polymerization1. Induces apoptosis in a variety of cell lines2. Inhibits autophagosome maturation3. Inhibits palmitoylation of tubulin4.
Biochemicals & reagents
143-67-9
Vincaleukoblastine
1) Hamel et al. (1996), Antimitotic natural products and their interactions with tubulin; Med. Res. Rev., 16 207 2) Tsukidate et al. (1993), Microtubule antagonists activate programmed cell death (apoptosis) in cultured rat hepatocytes; Am. J. Pathol., 143 918 3) Satori et al. (2013), Describing autophagy via analysis of individual organelles by capillary electrophoresis with laser induced fluorescence detection; Anal. Chem., 85 11391 4) Caron and Herwood (2007), Vinblastine, a chemotherapeutic drug, inhibits palmitoylation of tubulin in human leukemic lymphocytes; Chemotherapy, 53 51
-20°C
TARGET: Cytoskeleton; Lysosome -- PATHWAY: Cell cycle; Posttranslational modification; Apoptosis inducer; Autophagy -- RESEARCH AREA: Cell death; Vesicles -- DISEASE AREA: Cancer