Amphotericin B
Antifungal agent / Amphotericin B is a powerful antimycotic, effective against a wide variety of fungi, including yeast, via two mechanisms: forming pores in the plasma membrane, leading to leakage and death1, and causing oxidative stress2. Other mechanisms have more recently been proposed, including formation of intracellular amphotericin B-containing vesicular bodies that target vacuoles3. Amphotericin B is also effective against some parasites, such as Leishmania spp4. Because of its potency and broad-spectrum activity, it is a common additive used to maintain sterility in cell culture and viral transport media.
Biochemicals & reagents
1397-89-3
NSC 527017
1) Kinsky et al. (1970), Antibiotic interaction with model membranes; Annu. Re. Pharmacol., 10 119 2) Sokol-Anderson et al. (1986), Amphotericin B-Indocued Oxidative Damage and Killing of Candida Albicans; J. Infect. Dis., 154 75 3) Grela et al. (2019), Modes of the antibiotic activity of amphotericin B against Candida albicans; Sci. Rep., 9 17029 4) Paila et al. (2010), Amphotericin B inhibits entry of Leishmaniz donovani into primary macrophages; Biochem. Biophys. Res. Commun., 399 429
-20°C / Protect from light
TARGET: Antibiotic; Ionophore -- DISEASE AREA: Parasites; Infectious disease